鹅去氧胆酸试剂厂家直销，上海沪峥质量稳定，可靠，是我公司主打产之一，公司有用一支强大的研发团队，针对生化细分领域，团结合作，为各大高校和科研实验室提供质量稳定，可靠的生化试剂，包括生物试剂（BR级），优等纯试剂（GR级），超纯试剂（UR级），分析纯试剂（AR级），实验试剂（LR级）等各等级的试剂。

鹅去氧胆酸试剂基本资料：

【中文名称】鹅去氧胆酸

【英文名称】Chenodeoxycholic acid

【CAS号】  474-25-9

【纯度】≥99%

【类别】AR/BR

【产地】国产、进口

敏感性 对光敏感

密度 1.1280

溶解性 Soluble in ethanol (~20 mg/ml), methanol, acetone, glacial acetic acid, DMF, DMSO, and 1:1 DMF:PBS(pH 7.2) (~0.5 mg/ml). Insoluble in water.

存贮条件 密封避光保存。

产品介绍 Chenodeoxycholic Acid, Free Acid and its 7β-isomer ursodeoxycholic acid are potent (nanomolar affinity) selective inhibitors of DD2 (AKR1C2). These compounds were non-competitive inhibitors of AKR1D1 yielding Ki values of 3.2 μM for chenodeoxycholic acid. This chemical is a hydrophobic primary bile acid, which increases intracellular Ca2+ in rat hepatocyte couplets. Studies indicate that Chenodeoxycholic Acid induces apoptosis through a PKC dependent pathway. It is known that Chenodeoxycholic Acid is essential in the metabolism of cholesterol via activation of nuclear receptors. This bile acid can also bind to BABP with a stoichiometery of 1:2. Alternate studies indicate that chenodeoxycholic acid can inhibit the expression of IL-6 and cell viability in QBC939 cells.

别名 脱氧鹅胆酸;鹅脱氧胆酸;3α,7α-二羟基胆质酸;3α,7α-二羟基-5-β-胆烷酸; 脱氧脲苷;护肝素;3α,7α-Dihydroxy-5β-cholanic acid; 5β-Cholanic acid-3α,7α-diol Chenodiol;5β-Cholanic Acid-3α,7α-diol

生化机理

Chenodeoxycholic Acid (CDCA), is a hydrophobic primary bile acid that activates nuclear receptors involved in cholesterol metabolism. Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulates genes involved in lipid metabolism. EC50 concentrations for activation of FXR range from 13-34 μM. In cells, Chenodeoxycholic Acid also binds to bile acid binding proteins (BABP) with a reported stiochiometery of 1:2. Chenodeoxycholic Acid toxicity is linked to increased cellular glutathione levels and increased oxidative stress. Exposure of cells to excess Chenodeoxycholic Acid contributes to liver and intestinal cancers.

应用 An apoptosis inducer via PKC-dependent signalling pathway.

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鹅去氧胆酸试剂*上海沪峥：

1.上海沪峥始终如一的坚持产品质量用心，售后服务用心，客户放心的原则，建立了产品安全评估机构，严格执行产品安全的宗旨和理念，向客户提供优质的试剂和其他生物制品。

2.公司代理Sigma-Aldrich，Amresco，Serva, Alfa，TCI等国内外知名试剂品牌，以专业的经营态度满足科研实验室，高校实验室等不同客户的不同专业需求，同时与国内众多实验室和高校长期合作，保证产品的稳定，可靠！

3.公司产品覆盖面广，种类齐全，质量稳定，价格亲民，公司自制及进口试剂都经过公司专业人员检测后，再发送到终端客户使用。主营试剂类为：色素类，碳水化合物类，植物激素及核酸类，酶类，抗生素类，培养基类，蛋白质类，氨基酸类，维生素类等，满足不同客户的不同实际需求。