来普霉素B试剂质量稳定，可靠，是我公司主打产之一，公司有用一支强大的研发团队，针对生化细分领域，团结合作，为各大高校和科研实验室提供质量稳定，可靠的生化试剂，包括生物试剂（BR级），优等纯试剂（GR级），超纯试剂（UR级），分析纯试剂（AR级），实验试剂（LR级）等各等级的试剂。

来普霉素B试剂基本资料：

【中文名称】来普霉素B

【英文名称】Leptomycin B

【CAS号】 87081-35-4                

【纯度】≥99%

【类别】AR/BR

【产地】国产、进口

密度 1.0720

溶解性 Soluble in ethanol or methanol. Ethanol is recommended. Unstable in DMSO

存贮条件 储存温度:-20℃

产品介绍 Leptomycin B is an anti-fungal antibiotic, anti-tumor cytotoxin that inhibits CRM1-dependent, NES-dependent nucleo-cytoplasmic translocation (nuclear export inhibitor). NES containing proteins include HIV-1 REV; actin, c-Abl, cyclin B1, MDM2/p53, IB, MPF, PKA and MEK.

别名 Leptomycin B;Mantuamycin;Mantuamycin; LMB; Elactocin

生化机理 Leptomycin B is an unsaturated, branched-chain fatty acid, and is an important tool in the study of nuclear export. It is a specific inhibitor of proteins containing nuclear export signal. It inhibits nucleo-cytoplasmic translocation of molecules such as the HIV-1 Rev protein and Rev-dependent export of mRNA. The addition of very small amounts to fibroblasts causes accumulation of MEK in the nucleus. Other proteins that are influenced by leptomycin B are actin, c-Abl, cyclin B1, MDM2/p53, IκB, MPF, and PKA. The suggested inhibition mechanism involves the direct binding of leptomycin B to CRM1, which blocks the binding of CRM1 to proteins containing the nuclear export signal, via the interaction with cysteine residue in CRM1 control conserved region.

应用 Leptomycin B is a potent and specific nuclear export inhibitor. Leptomycin B alkylates and inhibits CRM1 (chromosomal region maintenance)/exportin 1, a protein required for nuclear export of proteins containing a nuclear export sequence (NES). In addition to antifungal and antibacterial activities, Leptomycin B blocks the cell cycle and is a potent anti-tumor agent. At low nM concentrations, Leptomycin B blocks the nuclear export of many proteins including HIV-1 Rev, MAPK/ERK, and NF-κB/IκB, and it stabilizes the expression of p53. Leptomycin B also inhibits the export and translation of many RNAs, including COX-2 and c-Fos mRNAs, by inhibiting export of ribonucleoproteins.

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来普霉素B试剂*上海沪峥：

1.上海沪峥始终如一的坚持产品质量用心，售后服务用心，客户放心的原则，建立了产品安全评估机构，严格执行产品安全的宗旨和理念，向客户提供优质的试剂和其他生物制品。

2.公司代理Sigma-Aldrich，Amresco，Serva, Alfa，TCI等国内外知名试剂品牌，以专业的经营态度满足科研实验室，高校实验室等不同客户的不同专业需求，同时与国内众多实验室和高校长期合作，保证产品的稳定，可靠！

3.公司产品覆盖面广，种类齐全，质量稳定，价格亲民，公司自制及进口试剂都经过公司专业人员检测后，再发送到终端客户使用。主营试剂类为：色素类，碳水化合物类，植物激素及核酸类，酶类，抗生素类，培养基类，蛋白质类，氨基酸类，维生素类等，满足不同客户的不同实际需求。