根赤壳菌素试剂质量稳定，可靠，是我公司主打产之一，公司有用一支强大的研发团队，针对生化细分领域，团结合作，为各大高校和科研实验室提供质量稳定，可靠的生化试剂，包括生物试剂（BR级），优等纯试剂（GR级），超纯试剂（UR级），分析纯试剂（AR级），实验试剂（LR级）等各等级的试剂。

根赤壳菌素试剂基本资料：

【中文名称】根赤壳菌素

【英文名称】Radicicol

【CAS号】 12772-57-5     

【纯度】≥99%

【类别】AR/BR

【产地】国产、进口

敏感性 对热、光和空气敏感

密度 1.3640

溶解性 Soluble in DMSO and ethanol (10mg/mL)

存贮条件 储存温度:-20℃

产品介绍 Radicicol, a microbial cell differentiation modulator originally extracted from Neocosmospora tenuicristata, has been shown to inhibit proliferation and plasminogen activator production by vascular endothelial cells. Radicicol inhibits the expression of Cox-2 (IC50 = 27 nM) without affecting Cox-1 expression in LPS-stimulated macrophages. It is also a potent inhibitor of Hsp90. Experiments suggest that radicicol reduces the intracellular level of autophosphorylation of p60v-src as well as other tyrosine-phosphorylated proteins via inhibition of SRC kinases. In addition, radicicol has demonstrated the ability to inhibit K-ras signaling pathway which includes phosphorylation of Raf-1, MAPKK, and MAPK.

别名 根赤壳霉素;Monorden [1aS-(1aR*,2Z,4E,14*,15aR*)]-8-Chloro-1a,14,15,15a-tetrahydro-9,11-dihydroxy-14-methyl-6H-oxireno[e][2]benzoxacyclotetradecin-6,12(7H)-dione;Monorden

生化机理 Antifungal macrolactone antibiotic that inhibits protein tyrosine kinase. Radicicol induces the differentiation of HL-60 cells into macrophages, blocking cell cycle at G1 and G2. It suppresses NIH 3T3 cell transformation by diverse oncogenes such as src, ras and mos and also suppresses the expression of mitogen-inducible cyclooxygenase-2. As a cell differentiation modulator, radicicol has anti-angiogenic activity in vivo, inhibiting the proliferation of and plasminogen activator production by vascular endothelial cells

应用 A potent inhibitor of Hsp90, SRC, and Cox-2

【订购方式】可通过本页面QQ等联系方式联系客服销售，或致电页面上电话与我司销售人员联系，我们将第一时间回复您！

根赤壳菌素试剂*上海沪峥：

1.上海沪峥始终如一的坚持产品质量用心，售后服务用心，客户放心的原则，建立了产品安全评估机构，严格执行产品安全的宗旨和理念，向客户提供优质的试剂和其他生物制品。

2.公司代理Sigma-Aldrich，Amresco，Serva, Alfa，TCI等国内外知名试剂品牌，以专业的经营态度满足科研实验室，高校实验室等不同客户的不同专业需求，同时与国内众多实验室和高校长期合作，保证产品的稳定，可靠！

3.公司产品覆盖面广，种类齐全，质量稳定，价格亲民，公司自制及进口试剂都经过公司专业人员检测后，再发送到终端客户使用。主营试剂类为：色素类，碳水化合物类，植物激素及核酸类，酶类，抗生素类，培养基类，蛋白质类，氨基酸类，维生素类等，满足不同客户的不同实际需求。