Apicidin试剂质量稳定，可靠，是我公司主打产之一，公司有用一支强大的研发团队，针对生化细分领域，团结合作，为各大高校和科研实验室提供质量稳定，可靠的生化试剂，包括生物试剂（BR级），优等纯试剂（GR级），超纯试剂（UR级），分析纯试剂（AR级），实验试剂（LR级）等各等级的试剂。

Apicidin试剂基本资料：

【中文名称】Apicidin

【英文名称】Apicidin

【CAS号】183506-66-3

【纯度】≥99%

【类别】AR/BR

【产地】国产、进口

密度 1.2700

溶解性 Soluble in DMSO (~1 mg/mL), acetonitrile (~1 mg/mL), ethanol (1 mg/mL), and methanol.

存贮条件 储存温度:-20℃

产品介绍 Apicidin, a fungal metabolite, contains potent and broad antiprotozoal characteristics in vitro against Apicomplexan parasites. This compound has also been shown to be active in mice against Plasmodium berghei. Apicidin is an HDAC inhibitor. Mechanistic studies utilizing Apicidin inhibition in low nanomolar concentration has been shown to cause hyperacetylation of histones in the Apicomplexan HDAC (histone deacetylase), which causes hyperacetylation of histones within the parasite. It has been reported that Apicidin also contains a wide range of antiproliferative activity against various cancer cell lines in mice, again through HDAC inhibition. Apicidin has also been shown to stimulate apoptosis via induction of Fas/Fas ligand. Furthermore, it has been reported to dramatically decrease HIF-1α levels and therefore reduce transcriptional activity of HIF-1 in murine cell lines. Apicidin is an inhibitor of HDAC3 and N-CoR.

别名 制蚜菌素;组蛋白脱乙酰酶抑制剂;Cyclo[(2S)-2-amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinexcarbonyl]

生化机理 Apicidin is a cyclic tetrapeptide that inhibits histone deacetylase. Apicidin has antiproliferative activity on various cancer cell lines and HeLa cells, accompanied by cell arrest at the G1 phase. It has been shown to induce selective changes in the expression of p21 and gelsolin, induce apoptosis in HL60 cells, and exhibit antiprotozoal, antiparasitic, and potential antimalarial properties.

应用 Apicidin is a cyclic peptide antibiotic with broad spectrum antiparasitic and antiprotozoan activity. A histone deacetylase inhibitor, apicidin is anti-angiogenic and induces apoptosis.

【订购方式】可通过本页面QQ等联系方式联系客服销售，或致电页面上电话与我司销售人员联系，我们将第一时间回复您！

Apicidin试剂*上海沪峥：

1.上海沪峥始终如一的坚持产品质量用心，售后服务用心，客户放心的原则，建立了产品安全评估机构，严格执行产品安全的宗旨和理念，向客户提供优质的试剂和其他生物制品。

2.公司代理Sigma-Aldrich，Amresco，Serva, Alfa，TCI等国内外知名试剂品牌，以专业的经营态度满足科研实验室，高校实验室等不同客户的不同专业需求，同时与国内众多实验室和高校长期合作，保证产品的稳定，可靠！

3.公司产品覆盖面广，种类齐全，质量稳定，价格亲民，公司自制及进口试剂都经过公司专业人员检测后，再发送到终端客户使用。主营试剂类为：色素类，碳水化合物类，植物激素及核酸类，酶类，抗生素类，培养基类，蛋白质类，氨基酸类，维生素类等，满足不同客户的不同实际需求。